Abstract #2893
FAST 31 P measurements of the creatine kinase synthesis rate at 11.7T
Andrew Bresnen 1 and Timothy Q. Duong 1
1
UTHSCSA - Research Imaging Institute, San
Antonio, Tx, United States
This study developed a quick and robust protocol for
measurement of the forward creatine kinase rate of ATP
synthesis (
k
f,CK
)
in the rat brain at 11.7T. We adopted the
31
P
Four Angle Saturation Transfer (
31
P FAST)
experiment to minimize the TR, by using low flip angles,
and the number of data points required to calculate to
k
f,CK
.
Historically, in vivo
31
P
MT experiments suffer from low SNR resulting in long
scan times, often on the order of hours. The optimized
protocol provides robust measurements of
k
f,CK
in
~5mins.
k
f,CK
in
normal rat brains was 0.310.03s-1.
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