Abstract #2871
Echo planar spectroscopic imaging based temperature calibration at 7T and 3T for whole brain temperature measurement in rodents and humans
Bhanu Prakash KN 1 , Sanjay K Verma 1 , Yevgen Marchenko 1 , Sankar Seramani 1 , Suresh Anand Sadananthan 2 , Navin Michael 2 , Charmaine Childs 3 , Lu Jia 4 , Andrew A. Maudsley 5 , and Sendhil Velan S 1,6
1
Laboratory of Molecular Imaging, Singapore
Bioimaging Consortium, Singapore, Singapore,
2
Singapore
Institute for Clinical Sciences, Singapore, Singapore,
3
Centre
for Health and Social Care Research, Faculty of Health
and Wellbeing, Sheffield Hallam University, Sheffield,
United Kingdom,
4
Combat
Protection and Performance Lab, Defence Medical and
Environmental Research Institute, DSO National
Laboratories, Singapore, Singapore,
5
Miller
School of Medicine, University of Miami, Miami, Florida,
United States,
6
Clinical
Imaging Research Centre, Singapore, Singapore
Whole brain temperature mapping is of great interest for
investigating traumatic brain injuries. Single-voxel-spectroscopy
(SVS) and CSI approaches provides limited spatial
coverage in the brain, whereas 3D Echo-planar
spectroscopic imaging (EPSI), covers the entire brain
for investigating temperature and metabolism in
traumatic brain injury (TBI) subjects. Our study aims at
implementation of EPSI, calibration and validation of
the temperature measurement in brain phantoms using EPSI
and SVS at pre-clinical and clinical scanners, to study
and analysis of whole brain temperature in TBI studies
on rodents and humans.
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