Abstract #2855
Non-invasive imaging of deep venous thrombi by 19F MRI using targeted perfluorcarbon nanoemulsions
Sebastian Temme 1 , Christoph Grapentin 2 , Christine Quast 1 , Christoph Jacoby 1 , Zhaoping Ding 3 , Friederike Mayenfels 4 , Jrgen Schrader 1 , and Ulrich Flgel 1
1
Molecular Cardiology, University of
Dsseldorf, Dsseldorf, NRW, Germany,
2
Pharmaceutical
Technology and Biopharmacy, University of Freiburg,
Freiburg, BW, Germany,
3
Molecular Cardiology,
University of Dsseldorf, Dsseldorf, Germany,
4
University
of Freiburg, Freiburg, BW, Germany
Detection of deep venous thrombi which are not
accessible by ultrasound is still a serious challenge.
Therefore a non-invasive technique for unequivocal
identification of those thrombi for diagnosis and
subsequent monitoring of antithrombotic therapy would be
highly desirable. Therefore we applied a novel
sterol-based post-insertions technique to generate
stable
2-antiplasmin
targeted PFC-NE for the rapid, highly specific and
unequivocal identification of freshly developed deep
venous thrombi, which might have a potential clinical
application in detection of rethrombosis or lung
thromboembolism. Moreover, we propose that the
sterol-based post-insertion technique is a promising
platform to equip PFC-NE with different ligands
(peptides, antibodies etc.) for in-vivo 19F MRI of
specific targets.
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