Abstract #2845
Clustering and rationing of Gd-enhanced voxels by injection of Gd-labelled RBC, a tool to quantify functional information from MR images
Enza Di Gregorio 1 , Giuseppe Ferrauto 1 , Stefania Lanzardo 1 , Eliana Gianolio 1 , and Silvio Aime 1
1
Molecular Biotechnologies & Health Sciences,
University of Torino, Torino, Italy
Different MRI contrast agents have been developed as
blood pool agents and are currently used in clinical
and/or pre-clinical applications. One of the issues
related to their use deals with their possible
extravasations. Herein, we suggest a new way to get rid
of this problem by using Gd-labelled RBCs that remain
fully confined in the blood vasculature. Since tumor
vasculature is one of the most intensively investigated
aspects of the tumor growth the evaluation of vascular
volume inside tumor region is of huge interest for the
tumor staging and for the evaluation of anti cancer
treatments.
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