Abstract #2825
The effect of mesenchymal stem cells on vascularization of an artificial transplant cell site studied by DCE-MR and bioluminescence imaging
Andrea Galisova 1 , Daniel Jirak 1 , Eva Fabryova 2 , Vit Herynek 1 , Eva Dovolilova 2 , Jan Kriz 2 , and Milan Hajek 1
1
MR Unit, Department of Diagnostic and
Interventional Radiology, Institute for Clinical and
Experimental Medicine, Prague, Czech Republic, Czech
Republic,
2
Center
for Experimental Medicine, Institute for Clinical and
Experimental Medicine, Prague, Czech Republic, Czech
Republic
Sufficient blood supply to the transplanted cells is
crucial for their survival and can be enhanced by
implantation of stem cells. We examined the effect of
stem cells on vascularization of artificial scaffolds
intended for pancreatic islet transplantation by Dynamic
Contrast Enhancement MR. Presence of genetically
modified stem cells was confirmed by bioluminescence
imaging. We observed increased perfusion in the devices
simultaneously with optical signal within 2 months
following stem cells implantation. Our results indicate
that stem cells improve vascularization inside the
chambers what ameliorates the transplantation outcome.
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