Abstract #2802
1 H/ 19 F MRI of histological tumor sections using a double tunable surface coil
Gunthard Lykowsky 1 , Thomas Christian Basse-Lsebrink 1 , Thomas Kampf 2 , Michael Hess 3 , Stephanie Weibel 3 , Aladar A. Szalay 4 , Peter Michael Jakob 1,2 , and Daniel Haddad 1
1
Research Center for Magnetic Resonance
Bavaria e.V., Wrzburg, Bavaria, Germany,
2
Department
for Experimental Physics 5, University of Wrzburg,
Bavaria, Germany,
3
Department of Biochemistry,
University of Wrzburg, Bavaria, Germany,
4
Genelux
Corporation, San Diego, CA, United States
Within the last few years, 19F MRI was successfully
applied to numerous research questions. For 19F-based
cell tracking, ex-vivo MRI in combination with
immunohistochemistry is often performed to validate
in-vivo findings. Unfortunately, due to different sample
geometries and sizes, the correlation of the different
imaging modalities is limited. For 1H MRI, coils
optimized for imaging of histological samples have been
successfully applied. The current work expands the
concept of 1H MRI on histological tissue samples to
1H/19F MRI using a double-tunable surface coil, thus
allowing correlation between the 1H/19F MR data and
histology.
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