Abstract #2783
A Multi-compartment Phantom for Controlled and Heterogeneous Conversion of Hyperpolarized [1-13C]-Pyruvate to Lactate
Christopher M Walker 1 , Mark S Ramirez 1 , Jaehyuk Lee 1 , and James A Bankson 1
1
Imaging Physics, M.D. Anderson, Houston,
Texas, United States
One barrier to efficient development and validation of
advanced imaging techniques for hyperpolarized agents is
then current lack of a practical model for the complex
biology probed by hyperpolarized MR. To fill this need
we propose a multi compartment single enzyme phantom
that allows repeatable conversion of pyruvate to lactate
in a tunable manner for mimicking different tissue
states. We have demonstrated the phantoms spatial
dependence with both multichannel spectral measurements
and cumulative spectral Imaging. This platform has the
potential to speed development and implementation of
complex imaging strategies for efficient hyperpolarized
MR.
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