Abstract #2772
Thermal T 1 measurements for frequently used 13 C hyperpolarization agents at clinically available field strengths
Stephan Dwel 1,2 , Patrick Christ 1,3 , Ulrich Kllisch 1,3 , Markus Durst 1,3 , Concetta V Gringeri 3,4 , Franz Schilling 4 , Marion I Menzel 3 , Rolf F Schulte 3 , Steffen Glaser 2 , Markus Schwaiger 4 , and Axel Haase 1
1
Institute of Medical Engineering, Technische
Universitt Mnchen, Garching, Germany,
2
Department
of Chemistry, Technische Universitt Mnchen, Garching,
Germany,
3
GE
Global Research, Garching, Germany,
4
Institute
of Nuclear Medicine, Klinikum Rechts der Isar, Munich,
Germany
Through hyperpolarized
13
C
MRSI, the labeled compounds pyruvate, alanine, lactate,
urea and acetate allow real-time in-vivo studies of
energy metabolism, perfusion and short chain fatty acid
metabolism, respectively. In hyperpolarized experiments,
the signal-to-noise-ratio is independent of the magnetic
field strength B
0
, but spectral resolution
and spin-lattice relaxation times T
1
can
strongly depend on B
0
. We measured T
1
for
the five aforementioned compounds at clinically
available field strengths (1T, 3T, 7T) and 14T with
constant pH and temperature in a buffer solution. Within
the statistical uncertainty, T
1
decreases
with increasing B
0
for
all substances, but the degree depends on the compound.
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