Abstract #2765
Development of a Novel 2DRF Pulse Sequence to Achieve Improved Localization in Hyperpolarized 13 C Imaging
Shuyu Tang 1 , Hsin-Yu Chen 1 , Robert A. Bok 1 , Daniel B. Vigneron 1 , and Peder Larson 1
1
Department of Radiology and Biomedical
Imaging, UCSF, San Francisco, California, United States
Hyperpolarization of metabolically active compounds
labeled with
13
C
is an emerging approach for imaging metabolic processes
in vivo. We designed a new two-dimensional
spatially-selective radiofrequency (2DRF) pulse for
bolus tracking in hyperpolarized
13
C
imaging. Advantages of applying 2DRF in hyperpolarized
13
C
imaging include reducing polarization loss and
shortening acquisition time. Due to the use of a spiral
excitation trajectory, our design allows for minimal
perturbation of other off-resonance metabolites. Since
our 2DRF pulse was developed for a 3T clinical scanner
with conventional gradient performances, rapid
translation of our design to human studies is possible.
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