Abstract #2743
Comparison of contrast concentration conversion methods for pharmacokinetic analysis of Dynamic Contrast Enhanced (DCE) MRI in the thin vessel wall: T1 mapping is not worthwhile by introducing more variance
Tingting Wu 1 , Jinnan Wang 2 , Yan Song 3 , Xiaotao Deng 3 , Xihai Zhao 1 , Rui Li 1 , Anqi Li 3 , Shuo Chen 1 , Chun Yuan 1,4 , and Huijun Chen 1
1
Center for Biomedical Imaging Research,
Tsinghua University, Beijing, Beijing, China,
2
Philips
Research North America, Briarcliff Manor, New York,
United States,
3
Beijing
Hospital, Beijing, China,
4
Dept.
of Radiology, University of Washington, Seattle,
Washington, United States
We evaluated the reproducibility of pharmacokinetic
measurement by using contrast concentration conversion
with pre-T1 mapping in DCE-MRI of experimental thin
vessel wall (thickness < 1mm). We found that
concentration conversion with pre-T1 mapping has poorest
reproducibility, compared with normalized intensity
curves and contrast concentration conversion with fixed
pre-T1. Thus, adding pre-T1 mapping for concentration
conversion in the analysis of DCE-MRI is not worthwhile
on thin vessel wall imaging. Both concentration
conversion with assumed pre-T1 or directly using the
normalized signal curves are more preferable.
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