Tracer-kinetic field analysis in DCE-MRI and DSC-MRI: the reconstruction problem

Tracer-kinetic field theory models indicator transport as an exchange between voxels and thus eliminates bolus-dispersion errors caused by the assumption of a global AIF. Here a numerical approach is proposed to reconstruct the parameter fields from the measured concentrations. Initial simulations are performed to investigate practicality and stability with respect to noise and temporal undersampling. The results suggest that the reconstruction is feasible on standard PCs and provides accurate results at realistic levels of noise and temporal resolution. A practical advantage is that the boundary concentrations can be reconstructed, eliminating the need for a separate AIF measurement.

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