Abstract #2680
Assessing microstructural substrates of white matter abnormalities using NODDI - application to a metabolic disease
Inge Timmers 1,2 , Alard Roebroeck 1 , Matteo Bastiani 1,3 , Bernadette Jansma 1 , Estela Rubio-Gozalbo 2 , and Hui Zhang 4
1
Department of Cognitive Neuroscience,
Maastricht University, Maastricht, Netherlands,
2
Department
of Pediatrics, Maastricht University Medical Center,
Maastricht, Netherlands,
3
Institute
of Neuroscience and Medicine, Forschungszentrum Juelich
GmbH, Juelich, Germany,
4
Department
of Computer Science & Centre for Medical Image
Computing, University College London, London, United
Kingdom
This work demonstrates
neurite
orientation dispersion and density imaging
(NODDI)
as a tool for investigating microstructural substrates
of white matter abnormalities in a clinical population.
NODDI estimates indices of neurite density (NDI) and
orientation dispersion (ODI), two key contributors of
fractional anisotropy (FA) from diffusion tensor imaging
(DTI). We show that NODDI analysis of multi-shell
diffusion-weighted data adds microstructural specificity
to the findings from DTI. Findings from the NODDI
indices overlap substantially with FA, revealing the
specific microstructural changes corresponding to the
latter. We additionally demonstrate that NODDI analysis
of single-shell data can potentially be used for
detecting ODI changes.
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