Abstract #2655
Calibrated Diffusion Phantom for 7T MRI
Joelle E Sarlls 1 , Carlo Pierpaoli 2 , Qi Duan 3 , Wolfgang Devine 4 , and Hellmut Merkle 3
1
NINDS/NMRF, National Institutes of Health,
Bethesda, MD, United States,
2
NICHD/STBB,
National Institutes of Health, MD, United States,
3
NINDS/LFMI,
National Institutes of Health, MD, United States,
4
NINDS-NIMH/RSB,
National Institutes of Health, Bethesda, MD, United
States
Although 7T provides increased MR signal, attractive to
signal-starved diffusion imaging, there are also
technical challenges like increase B1 inhomogeneity and
susceptibility effects. Accordingly, there is much
activity in sequence and hardware development. We
introduce a calibrated diffusion phantom that provides
the means to accurately test developed sequences and
hardware at 7T. We utilized a 35% PVP solution providing
a known diffusion coefficient, close to in-vivo brain,
and mitigating flow effects. We show that utilizing a
17cm cylindrical shaped container fitted with a grid of
1x1cm plastic columns dramatically improves B1
homogeneity, removing bias in the calculated diffusion
coefficient.
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