Abstract #2639
Apparent exchange rate (AXR) mapping in diffusion MRI: An in vivo test-retest study and analysis of statistical power.
Bjrn Lampinen 1 , Filip Szczepankiewicz 1 , Danielle van Westen 2 , Pia Sundgren 2 , Freddy Sthlberg 1,2 , Jimmy Ltt 3 , and Markus Nilsson 4
1
Dpt. of Medical Radiation Physics, Lund
University, Lund, Sweden,
2
Dpt.
of Diagnostic Radiology, Lund University, Lund, Sweden,
3
Center
for Medical Imaging and Physiology, Lund University
Hospital, Lund, Sweden,
4
Lund
University Bioimaging Center, Lund University, Lund,
Sweden
Water exchange can be mapped noninvasively in diffusion
MRI using filter-exchange imaging (FEXI) to obtain the
apparent exchange rate (AXR). We here aim to prepare
FEXI for future clinical research that investigates
differences in mean AXR across populations. A
test-retest study is conducted on 18 healthy volunteers
to assess how inter-subject differences and measurement
error contribute to variance in AXR in various brain
regions. A power analysis is then performed to interpret
AXR variance in terms of study group sizes required to
detect a range of differences while ensuring a
statistical power of 0.8. We show that with study groups
under 10 subjects, mean differences between populations
of 40-80% in AXR, depending on the region, can be
detected.
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