Abstract #2634
In vivo oscillating gradient diffusion MRI provides unique microstructural information in normal and hypoxic-ischemic injured mouse brains
Dan Wu 1 , Frances J Northington 2 , and Jiangyang Zhang 3
1
Biomedical Engineering, Johns Hopkins
University School of Medicine, Baltimore, Maryland,
United States,
2
Pediatrics,
Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States,
3
Radiology,
Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States
In this study, we showed that in vivo oscillating
gradient spin echo (OGSE) diffusion MRI provided unique
tissue contrasts to delineate structures in the adult
mouse cerebellum. Comparisons between in vivo and ex
vivo OGSE data showed that death and fixation
significantly reduced OGSE ADC measurements and altered
their frequency dependency. In neonatal mouse brains
with hypoxic-ischemic injury, in vivo OGSE showed larger
increase in ADC with frequency in regions with cytotoxic
edema than normal tissues, and thereby reduced edema
contrast at high oscillating frequencies, which
suggested that the microstructural changes under
cytotoxic edema were within certain spatial scales.
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