Abstract #2618
An estimate of Gd-DOTA diffusivity in blood by direct NMR diffusion measurement of its hydrodynamic analogue Ga-DOTA
Christian Wieseotte 1,2 , Manfred Wagner 2 , and Laura Schreiber 1
1
Department of Radiology, Section of Medical
Physics, Johannes Gutenberg University Medical Center,
Mainz, Germany,
2
Max
Planck Institute for Polymer Research, Mainz, Germany
The diffusivity of contrast agents in the human body is
a fundamental property which is still a factor of
uncertainty in many applications. The main reason is
that due to the highly paramagnetic Gd
3+
ion,
direct observations by means of nuclear magnetic
resonance are not possible. This study pursues the
approach of directly measuring the diffusion of the
hydrodynamically analogue PET tracer Gd-DOTA in
deuterated water. The diffusivity in blood plasma can be
calculated by correcting for the higher solvent
viscosity. We report a diffusivity of Ga-/Gd-DOTA in
blood plasma at 310K of D = 2.92 (0.25)∙10
-10
m
2
s-1.
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