Abstract #2463
Dual Manganese- and Gadolinium-Enhanced Cardiac MRI Delineates the Peri-Infarct Region in Patients with Severe Ischemic Cardiomyopathy
Rajesh Dash 1 , Yuka Matsuura 1 , Paul J Kim 1 , Hadas Shiran 1 , Phillip Harnish 2 , Michael V McConnell 1,3 , and Phillip C. Yang 1
1
Stanford University, Stanford, CA, United
States,
2
Eagle
Vision Pharmaceutical Corporation, PA, United States,
3
Engineering,
Stanford University, Stanford, CA, United States
Delayed Enhanced MRI (DEMRI) with gadolinium (Gd) has
non-specific distribution properties and may
overestimate myocardial infarct size. Conversely,
Manganese (Mn2+) uptake into live, active cells via
L-type Ca2+ channels is specific for live cardiomyocytes.
From earlier work with animal MI models in our lab,
Manganese-Enhanced MRI (MEMRI) has demonstrated its
utility in identifying viable myocardium. We performed
dual-contrast DEMRI-MEMRI in humans with ischemic
cardiomyopathy. MEMRI infarct volumes were significantly
lower than DEMRI, similar to findings in small and large
animal models. MEMRI complements DEMRI to accurately
delineate the peri-infarct region and viable myocardium
in patients with ischemic heart disease.
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