Abstract #2453
An Analytic Description of Factors Affecting MOLLIs Accuracy Using a Time-Weighted Average Model of T 1 Relaxation
Kelvin Chow 1 and Richard B Thompson 1
1
Department of Biomedical Engineering,
University of Alberta, Edmonton, AB, Canada
The MOLLI sequence is commonly used for in-vivo cardiac
T
1
mapping
but is known to have systematic errors as a function of
heart rate, flip angle, T
1
, and T
2
.
We hypothesize that the apparent MOLLI relaxation rate
(R
1
*
) can be expressed as a time
weighted average (TWA) of the driven relaxation rate
during bSSFP readouts (R
1
'
) and
the true relaxation rate (R
1
) between
readouts. An algebraic expression for R
1
*
is
presented and validated through Bloch equation
simulations and phantom experiments. The TWA model
analytically describes the effects of many of MOLLIs
sources of error and provides insight into their
interaction.
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