Abstract #2404
Comparison of TRUST, projection-based T2 imaging with susceptometry-based oximetry for the quantification of venous oxygen saturation
Suliman A. Barhoum 1 , Zachary B. Rodgers 1 , Michael C. Langham 1 , Jeremy F. Magland 1 , and Felix W. Wehrli 1
1
Department of Radiology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States
Abnormal levels of CMRO2 are associated with a variety
of disorders of the central nervous system. The critical
step for CMRO2 quantification is estimation of venous
oxygen saturation (SvO2). Here, we compare SvO2 in the
superior sagittal sinus using three methods:
susceptometry-based oximetry (SBO), projection-based T2
(PT2), and TRUST. Average SvO2 was 654% (SBO), 673%
(PT2), and 614% (TRUST). There was good agreement among
the three methods with slightly lower values found with
TRUST (ANOVA, p<0.05). The main advantage of SBO over
PT2 and TRUST is the simultaneous measurement of
cerebral blood flow, which provides generally higher
temporal resolution.
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