Abstract #2394
In vivo Cardiac MRI Development for Studying Zebrafish Models of Myocardial Disease
Niranchana Manivannan 1 , Kelly Banks 2 , Anna Bratasz 3 , Debra Wheeler 2 , Matthew Joseph 2 , Ryan Huttinger 2 , Ray E. Hershberger 2 , and Kimerly A. Powell 3,4
1
Department of Electrical and Computer
Engineering, The Ohio State University, Columbus, Ohio,
United States,
2
Department
of Internal Medicine, The Ohio State University, Ohio,
United States,
3
Small
Animal Imaging Shared Resources, The Ohio State
University, Ohio, United States,
4
Department
of Biomedical Informatics, The Ohio State University,
Ohio, United States
Zebrafishs ability to regenerate cardiac muscle makes
it a good model for cardiovascular research. The goal of
this study is to explore the efficacy of MRI in in-vivo
cardiac imaging of adult zebrafish heart. Ex-vivo
studies are carried out to study the structure of the
heart in high resolution and to standardize the
acquisition geometry to localize the heart. In in-vivo
cine cardiac acquisition retrospective gating was used,
as prospective ECG and respiratory gating was not
possible. For the first time cardiac cine MRI in in-vivo
zebrafish heart is acquired using retrospective sequence
with navigator echo.
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