Abstract #2366
Quantification of L-type Calcium Channel Activity by Manganese-Enhanced MRI in Murine Hearts in Vivo
Kai Jiang 1,2 , Wen Li 1,2 , Raymond F. Muzic 1,3 , and Xin Yu 1,3
1
Department of Biomedical Engineering, Case
Western Reserve University, Cleveland, Ohio, United
States,
2
Case
Medical Center, Case Western Reserve University,
Cleveland, Ohio, United States,
3
Department
of Radiology, Case Western Reserve University,
Cleveland, Ohio, United States
In this study, a fast T
1
mapping
method was proposed for quantification of both the
arterial input function and the kinetics of Mn
2+
uptake
in mouse myocardium in manganese-enhanced MRI (MEMRI)
studies. A compartment model was developed for in vivo
estimation of Mn
2+
uptake
and efflux rates by fitting the model to MEMRI data.
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