Abstract #2333
Transient Permeability/ Perfusion Change during Microbubble-Facilitated Focused Ultrasound Blood-Brain Barrier Opening: A Small-Animal Observation
Wen Yen Chai 1,2 , Po Chun Chu 2 , Yu Chun Lin 1 , Jiun Jie Wang 3 , Yau Yau Wai 1 , and Hao Li Liu 2
1
Department of Medical Imaging and
Intervention, Chang Gung Memorial Hospital, Linkou,
Taiwan,
2
Department
of Electrical Engineering, Chang Gung University,
Taoyuan, Taiwan,
3
Department
of Medical Image and Radiological Sciences, Chang Gung
University, Taoyuan, Taiwan
The purpose of this study is to evaluate perfusion
change caused by FUS-BBB opening, and evaluate the
correlation with the permeability change. And the result
is that permeability increase after BBB opening highly
correlates with the cerebral blood volume increase, and
independent of the cerebral blood flow. This information
provides useful insights in understanding the
pharmacodynamic behavior when intending to apply this
approach to deliver drugs into the brain.
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