Abstract #2316
Water Relaxation Parameters and the State of Coagulation of a Protein for Vascular Repair
Ming Zhao 1,2 and Jerome L. Ackerman 2
1
University of Massachusetts Lowell, Lowell,
MA, United States,
2
MGH/MIT
Athinoula A. Martinos Center for Biomedical Imaging,
Charlestown, MA, United States
As part of a project to develop MR coagulation (MR-induced
RF heating of a coagulable biomaterial) for minimally
invasive repair of vascular lesions, we investigate the
relationship between the heat coagulation behavior and
MR relaxation properties of egg white. This protein
solution is a good model for the analogous behavior of
human serum albumin solution, an optimal (but expensive)
biomaterial for MR coagulation. We find that large
changes in both T2 and T1rho clearly indicate the
temperature at which the coagulation process occurs, as
validated by light scattering measurements.
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