Abstract #2311

Oxygen-dependence of T 1 in lung tissue as observed in isolated, ventilated porcine lung phantoms

Simon Triphan ^1,2 , Bertram Jobst ^1,3 , Paul Flechsig ^1,3 , Felix Breuer ² , Peter Jakob ² , and Jrgen Biederer ^1,4

¹ Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Baden-Wrttemberg, Germany, ² Research Centre Magnetic Resonance Bavaria e.V., Wrzburg, Bayern, Germany, ³ Translational Lung Research Center Heidelberg, Member of the German Lung Research Center (DZL), Heidelberg, Baden-Wrttemberg, Germany, ⁴ German Cancer Research Center (DKFZ), Heidelberg, Baden-Wrttemberg, Germany

T ₁ , the T ₁ -reduction induced by breathing pure oxygen, has been used for lung functional imaging. While this effect is primarily attributed to molecular oxygen (O ₂ ) dissolved in blood, the same also occurs in tissue. Capital Greek Delta

T ₁ thus provides a measure of lung function comprised of various aspects. The T ₁ reduction in tissue alone was examined using porcine lung explants in air and oxygen atmosphere. T ₁ reductions of 12%, similar to those observed in vivo were measured. T ₁ in the bloodless explants was found to be significantly shorter than in vivo . Additionally, a measurement of a preserved explant yielded even smaller T ₁ and Capital Greek Delta

T ₁ .

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