Abstract #2304
Gravitational Distribution Gradient of Inert Fluorinated Gases in Human Lungs Using 19 F Ultra-Short Echo Time MRI
Marcus J. Couch 1,2 , Iain K. Ball 2 , Tao Li 2 , Matthew S. Fox 2 , Birubi Biman 3,4 , and Mitchell S. Albert 1,2
1
Lakehead University, Thunder Bay, Ontario,
Canada,
2
Thunder
Bay Regional Research Institute, Thunder Bay, Ontario,
Canada,
3
Thunder
Bay Regional Health Sciences Centre, Thunder Bay,
Ontario, Canada,
4
Northern
Ontario School of Medicine, Thunder Bay, Ontario, Canada
It is well-known that pulmonary ventilation exhibits a
gravitational gradient due to a gradient in regional
compliance.
19
F
MRI, using inhaled inert fluorinated gases as a signal
source, is expected to exhibit strong ventilation
gradients, especially since the gas density is high. The
purpose of this study was to perform
19
F
3D UTE imaging in healthy volunteers, and to measure
anterior/posterior ventilation gradients. This
preliminary study demonstrates a clear gravitational
distribution gradient of inert fluorinated gases in
human lungs, and there is a potential for this technique
to provide functional and regional information regarding
lung physiology.
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