Abstract #2286
Assessment of Cystic Fibrosis in Pediatric Subjects using Hyperpolarized Xenon-129 MRI: Regional Mapping of Gas Uptake by Lung Tissue and Blood
Kun Qing 1 , Kai Ruppert 1,2 , Tally A. Altes 1 , G. Wilson Miller 1 , Yun Jiang 3 , Jaime F. Mata 1 , Yun M. Shim 1 , Chengbo Wang 1 , Steven Guan 1 , Iulian C. Ruset 4,5 , F. William Hersman 4,5 , and John P. Mugler 1
1
University of Virginia, Charlottesville, VA,
United States,
2
Cincinnati
Children's Hospital, Cincinnati, OH, United States,
3
Case
Western Reserve University, Cleveland, OH, United
States,
4
Xemed
LLC, Durham, NH, United States,
5
University
of New Hampshire, Durham, NH, United States
As a non-invasive MR imaging method, 3-D Xe129
dissolved-phase imaging is particularly suited to
monitoring functional changes of the lung and evaluating
treatment efficacy for CF subjects, especially those in
the pediatric population. In this study, we investigated
functional changes in 5 pediatric subjects with CF, as
compared with young healthy subjects. All tissue-to-gas
ratio maps were inhomogeneous, interestingly, for all CF
subjects imaged, the average tissue-to-gas ratios were
higher in the right lung than the left lung , and most
showed lower tissue-to-gas ratios in the right upper
lobe as compared to the other lobes in the right lung.
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