Abstract #2281
Comparison of Pulmonary 1 H non-contrast and Hyperpolarized 3 He MRI Ventilation Abnormalities in Bronchiectasis and COPD
Dante P Capaldi 1,2 , Fumin Guo 1,3 , Sarah Svenningsen 1,2 , Weijing Ma 1,2 , Khadija Sheikh 1,2 , Roya Etemad-Rezai 1 , Jonathon Leipsic 4 , Harvey O Coxson 4 , David G McCormack 5 , and Grace Parraga 1,2
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Department
of Medical Biophysics, The University of Western
Ontario, London, Ontario, Canada,
3
Graduate
Program in Biomedical Engineering, The University of
Western Ontario, London, Ontario, Canada,
4
Department
of Radiology, University of British Columbia, Vancouver,
British Columbia, Canada,
5
Department
of Medicine, The University of Western Ontario, London,
Ontario, Canada
Free-breathing non-contrast enhanced
1
H
MRI ventilation imaging using Fourier decomposition has
not yet been optimized at 3T or in patients with severe
chronic obstructive pulmonary disease (COPD) or
bronchiectasis in whom there are both airway and
parenchymal abnormalities. Our objective was to compare
FDMRI with hyperpolarized 3He MRI to visualize pulmonary
ventilation abnormalities in subjects with
bronchiectasis and COPD. Thirty subjects were evaluated
using hyperpolarized
3
He
MRI and FDMRI of the dynamic free tidal-breathing MRI
acquired over two minutes. There was excellent spatial
correlation between ventilation defects visualized using
both MR methods.
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