Study of chronological effects of iodinated contrast medium on intrarenal water molecular diffusion by diffusion-weighted MR imaging

Usage of iodinated contrast medium during radiological procedure may cause contrast induced nephropathy (CIN). Unfortunately the pathogenesis of CIN is currently unclear, and maybe characteristics of contrast medium affect the development of CIN. Our study demonstrated that it is feasible to monitor the time course effects on renal function after different iodinated contrast medium administration in rabbit models using diffusion-weighted MR imaging. Iopamidol-370 causes more deterioration on intrarenal water transport function than iodixanol-320. This may be helpful to understand the pathogenesis associated with CIN. We introduce a clinical clue to choose better contrast medium to prevent the incidence of CIN.

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