Abstract #2213
MicroMR Imaging of Renal Interstitial Fibrosis in a Unilateral Ureteric Obstruction Model
Septian Hartono 1,2 , Tong San Koh 1 , In Chin Song 3 , Lin Zheng 3 , Wing Sum Lee 3 , Laurent Martarello 4 , and Choon Hua Thng 1
1
National Cancer Centre Singapore, Singapore,
Singapore, Singapore,
2
Nanyang
Technological University, Singapore, Singapore,
Singapore,
3
SingHealth
Experimental Medicine Centre, Singapore, Singapore,
4
Roche
Translational Medicine Hub, Singapore, Singapore
We aim to determine if DCE-MRI and DWI can detect renal
interstitial fibrosis in mice. Renal fibrosis is induced
by unilateral ureteric obstruction (UUO) with survival
surgery. Six mice were scanned before the UUO procedure
dan one week after the UUO. Renal fibrosis is quantified
by amount of fibrosis as measured by Sirius Red stain.
There is a drop of ADC as derived from DWI and renal
parenchymal mean transit time (PMTT) as derived from DCE-MRI
in the cortices of the ligated kidneys. PMTT correlated
significantly with % of Sirius Red, signifying
potentials of using DCE-MRI as biomarker of renal
fibrosis.
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