Abstract #2207
Assessment of Renal Inflammatory Cell Infiltration in a Murine ANCA-Induced Glomerulonephritis Model by 19F-MRI
Andreas Pohlmann 1 , Adrian Schreiber 2 , Min-Chi Ku 3 , Helmar Waiczies 4 , Stefanie Kox 1 , Ralph Kettritz 2 , Sonia Waiczies 1 , and Thoralf Niendorf 1,5
1
Berlin Ultrahigh Field Facility, Max
Delbrueck Center for Moleculare Medicine, Berlin,
Germany,
2
Clinic
for Nephrology and Intensive Care Medicine, Campus
Virchow, Charit Medical Faculty, Berlin, Germany,
3
Berlin
Ultrahigh Field Facility, Max Delbrueck Center for
Molecular Medicine, Berlin, Germany,
4
MRI.TOOLS
GmbH, Berlin, Germany,
5
Experimental
and Clinical Research Center, Charite Medical Faculty
and the Max Delbrueck Center for Molecular Medicine,
Berlin, Germany
Anti-neutrophil cytoplasmic antibodies (ANCA) are
responsible for the development of small vessel
vasculitis. Currently, diagnosis of the initial
inflammation and its recurrences relies on kidney
biopsies, hence, the clinical need for non-invasive
methods. We have employed multi-modal fluorescently (DiI)
and 19F labeled nanoparticles to identify specific
inflammatory cell populations tested the hypothesis that
19F MRI after in-vivo 19F-labeling of monocytes and
neutrophils allows non-invasive detection of ANCA-induced
renal inflammation. Our data suggest that 19F-MRI may
represent a novel non-invasive method for the assessment
of renal inflammation in mouse models with the potential
of translation into a clinical tool for the diagnosis of
glomerulonephritis in patients.
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