Abstract #2144
Visual identification of brown adipose tissue in adult humans using Dixon MRI
Terence Jones 1 , Narendra Reddy 2 , Sarah Wayte 3 , Oludolapo Adesanya 4 , Thomas Barber 5 , and Charles Hutchinson 1
1
Medical School, University of Warwick,
Coventry, West Midlands, United Kingdom,
2
Metabolic
Health, University Hospitals Coventry & Warwickshire,
Coventry, CV2 2DX, United Kingdom,
3
Medical
Physics, University Hospitals Coventry & Warwickshire,
Coventry, CV2 2DX, United Kingdom,
4
Radiology,
University Hospitals Coventry & Warwickshire, Coventry,
West Midlands, United Kingdom,
5
Health
Sciences, University of Warwick, Coventry, West
Midlands, United Kingdom
Ongoing interest in brown adipose tissue (BAT) has led
to research in MRI as a potential tool for identifying
and quantifying BAT, which is a necessary precursor to
clinical trials evaluating pharmacological agents to
stimulate BAT. We conducted a study in which areas of
potential BAT were identified visually on Dixon MRI and
compared with metabolically BAT on PET-CT using
colocalization. Visual identification of BAT
underestimates BAT volume, particularly when large
levels of BAT are present. Conversely the degree of
colocalization increases with increasing BAT volumes.
This technique may be useful is evaluating future
methods of prospective BAT identification.
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