Abstract #2135
Evaluation of Hepatic Fat Fraction Measured by MRI and Plasma Lipoprotein Levels in High-Fat Diet Fed Non-Human Primate
Ai Leng Liang 1 , Catherine D. G. Hines 2 , Li Chun Huang 1 , Shian-Jiun Shih 1 , Donald S. Williams 2 , Elaine Manigbas 3 , Brian Henry 1 , Jeffrey L. Evelhoch 2 , and Chih-Liang Chin 1
1
Translational Medicine Research Centre, MSD,
Singapore, Singapore,
2
Imaging,
Merck & Co. Inc., West Point, Pennsylvania, United
States,
3
Imaging,
Maccine Pte Ltd, Singapore, Singapore
We have established non-human primate (NHP) models of
dyslipidemia by chronic feeding (9 mo.) two high-fat
diets to male cynomolgus monkeys. Compared to normal
diet fed NHPs, on average these animals (n=28) have
doubled their total cholesterol, HDL- and
LDL-cholesterol, but maintained triglyceride at baseline
level. Additionally, their MRI-derived hepatic fat
fraction (FF) increased from 2.4
0.6%
to 7.7
4.5%.
However, individual FFs do not correlate well with
lipoprotein levels or ratios, probably due to small
sample size and narrow data range. Our findings provide
insights into lipid metabolism dysfunction in the
dyslipidemic model and its potential utility for
translational research.
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