Abstract #2115
MRI colonic stress test for differentiating different subtypes of constipation
Gemma Chaddock 1 , Ching Lam 2 , Klara Garsed 2 , Caroline Hoad 1 , Carolyn Costigan 1 , Susan Pritchard 1 , Luca Marciani 2 , Robin Spiller 2 , and Penny Gowland 1
1
Physics & Astronomy, The University of
Nottingham, Nottingham, Nottinghamshire, United Kingdom,
2
NIHR
Nottingham Digestive Diseases Biomedical Research Unit,
Nottingham University Hospitals Trust, Nottingham,
Nottinghamshire, United Kingdom
We have assessed the colonic response of patients with
chronic constipation (CC) to a laxative, using novel MRI
methods. 40 patients took part in this one day open
label study where serial MRI was used to assess whole
gut transit time, small bowel water content, colonic
volumes and colonic motility following oral ingestion of
1 L of a macrogol based laxative. We found quantifiable
differences between the colonic responses of patients
with different types of CC following ingestion of the
laxative. This presents the opportunity to differentiate
between patients with different forms of CC, allowing
for more personalised treatment.
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