Abstract #2020
Perturbed CO2 reactivity within and beyond the impact area following hyperacute mild TBI
Justin Alexander Long 1 , Qiang Shen 1 , Lora Talley Watts 1 , Shiliang Huang 1 , and Timothy Duong 1
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
Texas, United States
The initial direct mechanical damage in traumatic brain
injury (TBI) is followed by secondary damage that
includes impaired cerebral blood flow, autoregulation,
and metabolic function. The goal of this study was to
longitudinally examine the vascular reactivity to CO2 in
mild TBI during hyperacute and chronic phase up to 14
days. Extensive and severe CO2 reactivity disruption
beyond the impact area was observed in hyperacute TBI.
Area of CO2 response abnormality appeared much larger
than CBF, T2, and ADC abnormality in the hyperacute
phase. T2 and CO2 reactivity mostly normalized by day 14
but mild hypoperfusion and reduced CO2 reactivity
remained on day 14. These multi-parametric MRI offers
complementary, clinically relevant information.
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