Abstract #2013
Neuroinflammation in Chronic Sports-Related Repetitive Brain Trauma
Alexander Peter Lin 1 , Molly Charney 1 , Huijun Vicky Liao 1 , Sai K Merugumala 1 , Christine Baugh 2 , and Robert A Stern 2
1
Radiology, Brigham and Women's Hospital,
Boston, MA, United States,
2
Center
for Study of Traumatic Encephalopathy, Boston University
School of Medicine, Boston, MA, United States
Chronic traumatic encephalopathy (CTE) is a
neurodegenerative condition that can result from
sports-related repetitive brain trauma. It is
characterized by the deposition of tau proteins which
may induce neuroinflammation. The goal of this study is
to measure neuroinflammation in retired NFL athletes at
high risk for CTE by measuring glutathione levels using
magnetic resonance spectroscopy. Our results show that
glutathione levels are reduced in NFL players when
compared to age-matched professional athlete controls
with no history of head injury. As GSH is utilized by
the brain to neutralize reactive oxidative species, the
reduction is reflective of neuroinflammation.
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