Abstract #2004
Assessment of Whole Brain Temperature in Brain Injuries by 3D Echo-Planar Spectroscopic Imaging
Bhanu Prakash KN 1 , Sanjay K Verma 1 , Yevgen Marchenko 1 , Sankar Seramani 1 , Kan Enci Mary 2 , Charmaine Childs 3 , Lu Jia 2 , Andrew A Maudsley 4 , and Sendhil Velan S 1,5
1
Laboratory of Molecular Imaging, Singapore
Bioimaging Consortium, Singapore, Singapore,
2
Combat
Protection and Performance Lab, Defence Medical and
Environmental Research Institute, DSO National
Laboratories, Singapore, Singapore,
3
Centre
for Health and Social Care Research, Faculty of Health
and Wellbeing, Sheffield Hallam University, United
Kingdom,
4
Miller
School of Medicine, University of Miami, Florida, United
States,
5
Clinical
Imaging Research Centre, Singapore, Singapore
Measurement of in vivo temperature is of relevance in
traumatic brain injuries including survival outcome of
patients. Whole brain 3D MRSI approach with larger
spatial coverage is highly desirable for assessing
changes in cerebral metabolism and investigation of hot
spots. 3D Echo-planar spectroscopic imaging (EPSI) on a
pre-clinical scanner was implemented to evaluate the
brain temperature changes in mild and severe traumatic
brain injuries (TBI) in rodents. Brain temperature
across the brain was investigated in mild and severe TBI
rodents. Reduction in acquisition time along with high
spatial resolution allows translation of this technology
to a clinical setting, and for investigating changes in
brain temperature due to TBI, stroke, cancer, epilepsy
and whole brain metabolic imaging in animals and humans.
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