Abstract #1994
Auditory GABA Concentration Is Related to Auditory Gamma-Band Power in Normal Controls and in Autism
Mark S. Brown 1 , Sarah Steinmetz 2 , Susan L. Hepburn 3 , Deb Singel 4 , and Donald C. Rojas 5
1
Radiology, University of Colorado Denver,
Aurora, CO, United States,
2
University
of Colorado Denver, Aurora, CO, United States,
3
Psychiatry
& Pediatrics, JFK Partners/University of Colorado School
of Medicine, Aurora, CO, United States,
4
Brain
Imaging Center, University of Colorado Denver, Aurora,
CO, United States,
5
Psychiatry, University of
Colorado Denver, Aurora, CO, United States
Auditory Gamma band MEG responses and auditory GABA
levels, measured with MRS J-editing techniques, were
measured in 25 healthy controls and 24 individuals with
autism spectrum disorder (ASD). The results show lower
GABA and transient gamma band power in the ASD subjects
compared to healthy controls. Transient gamma band power
correlated with GABA levels in the control group and
approached significance in the ASD group. The results
are consistent with our previous preliminary work
suggesting that auditory gamma band responses are
related to auditory GABA.
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