Abstract #1991
Less dynamic functional brain network in schizophrenia
Hu Cheng 1 , Sharlene Newman 1 , Joaquin Goni Cortes 1 , Jerillyn S. kent 1 , Josselyn Howell 1 , Amanda Bolbecker 1 , Aina Puce 1 , Brian F. O'Donnell 1 , and william P. Hetrick 1
1
Indiana University, Bloomington, IN, United
States
Recent studies indicate less dynamic brain function in
schizophrenia patients. Because head motion and other
confounds can affect the FC and its variability,
investigation of FC dynamics by directly comparing FC
over time can be invalid. We propose a method to tackle
this problem. By constructing two FCs from interleaved
time points of the resting state time course, we can
extract the variance of FC irrelevant to brain dynamics,
and use it as a baseline in the evaluation of FC change.
Using this approach, we found that the schizophrenia
patients exhibited smaller variations of functional
network compared to normal controls.
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