Abstract #1979
The amygdalar driving effects for overeating in Prader-Willi syndrome
Ju Liu 1 , Jianliang Yao 1 , Siyou Qiu 1 , Yi Zhang 1 , and Yijun Liu 2
1
School of Life Science and Technology,
Xidian University, Xi'an, Shanxi, China,
2
Department
of Biomedical Engineering, Peking University, Beijing
100871, China
Prader-Willi syndrome(PWS) is a genetic imprinting
disorder associated with hyperphagia and early childhood
obesity.To study the neurobiological drive for
overeating implicated in Prader-Willi syndrome,the
current study combined the resting-state fMRI and
Granger causality analysis (GCA) techniques to
investigate the interactive causal influences among key
neural pathways underlying overeating in PWS.Our data
revealed significantly enhanced causal influences from
theamygdala to the hypothalamus and from both the medial
prefrontal cortex and anterior cingulate cortex to the
amygdala. This study provides both a new methodological
and neurobiological perspective to aid in a better
understanding of neural mechanisms underlying common
dietary obesity in the general public.
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