Abstract #1970
Correlation of emotional-behavioral outcomes and white matter alterations in VLBW adolescents without overt disability
Ming-Chung Chou 1 , Ming-Ting Wu 2,3 , Hsiu-Lin Chen 4 , Yu-Chen Wu 1 , and Pinchen Yang 5
1
Department of Medical Imaging and
Radiological Sciences, Kaohsiung Medical University,
Kaohsiung, Taiwan,
2
Department
of Radiology, Kaohsiung Veterans General Hospital,
Kaohsiung, Taiwan,
3
School
of Medicine, National Yang Ming University, Taipei,
Taiwan,
4
Department
of Pediatrics & Department of Respiratory Therapy,
Kaohsiung Medical University & Kaohsiung Medical
University Hospital, Kaohsiung, Taiwan,
5
Department
of Psychiatry, Kaohsiung Medical University & Kaohsiung
Medical University Hospital, Kaohsiung, Taiwan
In humans, birth weight generally correlates to
gestational age and is easy to determine. Preterm
infants are vulnerable to brain injuries, and brain
injury due to prematurity and impaired brain development
are inextricably intertwined. Nevertheless, there are
few long-term brain MRI reports of adolescence born VLBW
without overt neurological or mental disability. This
study performed emotional-behavioral assessments and
voxel-based DTI analysis in adolescents born VLBW
without overt physical or mental disability. The results
showed significant differences in DTI indices and
emotional-behavioral outcomes between VLBW adolescents
and control subjects. Therefore, we concluded that
subtle WM alterations were significantly associated with
emotional-behavioral measures in VLBW adolescents
without overt disability.
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