Abstract #1965
Perfusion based functional connectivity in autism reveals hypo-perfusion and altered connectivity of the Default Mode Network associated with increased symptom severity
Kay Jann 1 , Devora Beck-Pancer 2 , Emily Kilroy 3 , Mirella Dapretto 4 , and Danny JJ Wang 1
1
Department of Neurology, University of
California, Los Angeles, Los Angeles, California, United
States,
2
)
Department of Psychiatry and Biobehavioral Sciences,
University of California, Los Angeles, Los Angeles,
California, United States,
3
Division
of Occupational Science, University of Southern
California, Los Angeles, California, United States,
4
Department
of Psychiatry and Biobehavioral Sciences, University of
California, Los Angeles, Los Angeles, California, United
States
The aim of the present study was to characterize
abnormal patterns of resting state network perfusion and
functional connectivity using pseudo-continuous ASL (pCASL)
perfusion MRI. PCASL-based resting state networks and
their baseline perfusion were identified using ICA in 12
children with autism spectrum disorder (ASD). Our
results show that altered perfusion in the DMN is
related to autism symptom severity. Further, reduced DMN
perfusion is associated with altered connectivity of
anterior and posterior DMN, suggesting an association
between baseline activity within networks, their
connectivity and potentially alterations in stimulus
processing and/or development of clinical symptoms in
ASD.
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