Abstract #1961
Regional EEG Theta Increase enhances fMRI activity findings in a simultaneous EEG/fMRI study during Auditory Hallucinations in Chronic Schizophrenic Patients
Beatriz Dionisio 1,2 , Gracin Garca Mart 1,3 , Conrado J Calvo 4 , Nicols Pearanda 2 , Ana Beatriz Solana 5 , J. A. Hernndez-Tamams 5 , Luis Mart-Bonmat 3 , and Julio Sanjun 1,2
1
University of Valencia, CIBERSAM, Valencia,
Valencia, Spain,
2
Instituto
de Investigacin Sanitaria, INCLIVA, Valencia, Valencia,
Spain,
3
Servicio
de Radiologa, Hospital Quirn de Valencia, Valencia,
Spain,
4
Instituto
ITACA-Bio. Universitat Politcnica de Valncia, Grupo
Electrofiosiologa y Bioingenera (GEB), Valencia,
Spain,
5
Fundacin
CIEN, Fundacin Reina Sofa, Madrid, Spain
The pathophysiology of Auditory Hallucinations in
Schizophrenia remains poorly understood due to the
complexity to capture the spontaneous episodes and lack
of knowledge about its neuronal dynamics. By using
simultaneous EEG/fMRI techniques, we aimed to identify
power spectral differences of brain waves, linking
regional findings to intrinsic hemodynamic activations
leading to AHs in chronic patients. Our results suggest
that simultaneous EEG/fMRI seems to be a promising
technique for thorough investigation on AHs neural
spatiotemporal mechanisms alleviating technical
limitations. Both modalities were correlated during the
spontaneous AHs, with specific regional increase in
theta EEG activity and hemodynamic activations in
auditory and language cortical areas.
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