Abstract #1959
Dose-Dependent Influence of Short-Term Binge Ethanol Intoxication on Cerebral Neurochemical Changes in Rats Detected by Ex Vivo 1H NMR Spectroscopy
Do-Wan Lee 1 , Jung-Whan Min 2 , Jung-Hoon Lee 1,3 , Sang-Young Kim 1 , Jin-Young Jung 1 , Kyu-Ho Song 1 , and Bo-Young Choe 1
1
Department of Biomedical Engineering, and
Research Institute of Biomedical Engineering, The
Catholic University of Korea, College of Medicine,
Seoul, Seoul, Korea,
2
Department of
Radiological Science, The Shingu University College of
Korea, Seongnam, Seongnam, Korea,
3
Department
of Radiology, Kyunghee Medical Center, Seoul, Korea
The aim of presesnt study was to assess the effects of
short-term binge ethanol intoxication on cerebral
metabolite changes among the controls (CNTL), the
low-dose-ethanol (LDE)-exposed, and the
high-dose-ethanol (HDE)-exposed rats, which were
determined with the ex vivo spectra. Our results showed
that the normalized tNAA, GABA, and GSH levels were
significantly altered among CNTL, LDE- and HDE-exposed
rats. Moreover, the 6 pairs of normalized metabolite
levels were significantly correlated in the individual
rat data. Our ex vivo 1H HR-MAS NMRS results suggested
some novel metabolic markers for the dose-dependent
influence of short-term binge ethanol intoxication in
the frontal cortex.
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