Abstract #1954
Diffusion Tensor Imaging Reveals White Matter Damage in the Optic Nerves of Alzheimers Patients
Christopher Nishioka 1 , Christina Poh 2 , and Shu-Wei Sun 2
1
University of California, Riverside, CA,
United States,
2
Loma
Linda University, CA, United States
Optic nerves of Alzheimers Disease (AD) patients were
analyzed with diffusion tensor imaging (DTI) and
compared to control patients. DTI scans were obtained
from the Alzheimers Disease Neuroimaging Initiative
(ADNI) database. Signs of white matter damage, including
decreased fractional anisotropy, increased radial
diffusivity and trace diffusion were seen in the AD
patient population. These changes may be indicative of
fiber loss and/or demyelination in the optic nerve.
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