Abstract #1947
Possible Compensatory Plasticity of Anterior Thalamic Nucleus to Memory Impairment In Normal Pressure Hydrocephalus Patients Manifested As Increased Anisotropy and Fiber Density
Yung-Chieh Chen 1 , Cheng-Yu Chen 2,3 , Shih-Wei Chiang 4,5 , Hsiao-Wen Chung 5 , Yu-Te Wu 1 , Ping-Huei Tsai 2 , Yi-Hsiu Hsiao 2 , Ming-Chung Chou 6 , Hung-Wen Kao 4 , and Chao-Ying Wang 4
1
Department of Biomedical Imaging and
Radiological Sciences, National Yang-Ming University,
Taipei, Taiwan,
2
Department
of Medical Imaging and Imaging Research Center, Taipei
Medical University Hospital, Taipei Medical University,
Taipei, Taiwan,
3
Graduate
Institue of Clinical Medicine, Taipei Medical
University, Taipei, Taiwan,
4
Department
of Radiology, Tri-Service General Hospital, Taipei,
Taiwan,
5
Graduate
Institute of Biomedical Electrics and Bioinformatics,
National Taiwan University, Taipei, Taiwan,
6
Department
of Medical Imaging and Radiological Sciences, Kaohsiung
Medical University, Kaohsiung, Taiwan
Idiopathic normal pressure hydrocephalus (NPH) is
manifested clinically with classic triad of gait
disturbance, incontinence and dementia. Quantification
of anisotropy in terms of metrics such as the fractional
anisotropy (FA) offers insight into microstructure
alternations. The purpose of this study is to examine
the diffusion tensor parametric behavior of anterior
thalamic nucleus in response to memory changes in normal
pressure hydrocephalus. Our study indicated that
alternations of diffusion tensor metrics can be measured
in thalamic nucleus responsible for memory in NPH
patient, which may have potential clinical implications
for responses monitoring at microstructure level in NPH
patients under treatment.
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