Abstract #1933
MRI Relaxometry Correlation against Iron in Alzheimers Disease
Christos Michaelides 1 , David J Lythgoe 1 , Harold G Parkes 2 , Claire Troakes 3 , Istvan Bodi 4 , Tina Geraki 5 , Amy H Herlihy 6 , and Po-Wah So 1
1
Department of Neuroimaging, Institute of
Psychiatry, King's College London, London, London,
United Kingdom,
2
CR-UK
Clinical MR Research Group, Institute of Cancer
Research, Sutton, Surrey, United Kingdom,
3
MRC
London Neurodegenerative Diseases Brain Bank, Department
of Clinical Neuroscience, Institute of Psychiatry,
Kings College London, London, United Kingdom,
4
Clinical
Neuropathology & London Neurodegenerative Diseases Brain
Bank, King's College London, Kings College Hospital,
London, United Kingdom,
5
Diamond
Light Source, Harwell Science and Innovation Campus,
Didcot, Oxfordshire, United Kingdom,
6
Agilent
Technologies, Yarnton, Oxfordshire, United Kingdom
Iron dysregulation may be a contributing factor to
neuronal cell death in Alzheimers disease. MR
relaxometry measurements in fixed post-mortem human AD
and control samples were correlated with direct iron
assessment by synchrotron-radiation X-ray fluorescence
mapping. AD did not affect iron concentrations or
relaxometry. Whilst R2 and R2* correlated with iron, R1
correlated less well, potentially due to significant
effects from fixation time. Increased iron in white
compared to grey matter is consistent with elevated iron
concentrations within white matter myelin. Our results
support R2 and R2* relaxometry in non-invasive
assessment of brain iron.
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