Abstract #1920
Comparison of Neuromelanin MRI with FP-CIT SPECT in Parkinson Disease
Paula Trujillo 1,2 , Paul Summers 1 , Giorgio Marotta 3 , Ioannis Isaias 4,5 , and Antonella Costa 1
1
Department of Neuroradiology, Fondazione
IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan,
MI, Italy,
2
Department
of Electronics, Information and Bioengineering,
Politecnico di Milano, Milan, MI, Italy,
3
Department
of Nuclear Medicine, Fondazione IRCCS Ca' Granda -
Ospedale Maggiore Policlinico, Milan, MI, Italy,
4
Centro
Parkinson, Istituti Clinici di Perfezionamento, Milan,
MI, Italy,
5
Neurologische
Klinik und Poliklinik, Universittsklinikum Wrzburg,
Bayern, Germany
Our aim was to compare contrast-to-noise ratio (CNR) and
volume measurements of the substantia nigra (SN) made
using NM-MRI with dopamine reuptake in the caudate
nucleus and putamen in Parkinsons disease patients as
measured using FP-CIT SPECT. Differences in NM-MRI
measures between healthy controls (HC) and Parkinsons
disease (PD) patients were also examined. Both NM-MRI
measures of the SN showed a significant correlation with
the FP-CIT binding values, and were significantly
different between the HC and PD groups. Our results
suggest that NM-MRI may find use in quantifying
pathology and following disease progression.
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