Abstract #1917
Dissociation Pattern in Resting-State Default Mode Network Connectivity in Type II Diabetes Patients
Ying Cui 1 , Yun Jiao 1 , Pei-Cheng Li 1 , Bing Luo 1 , Hai-Dong Zhu 1 , Cheng-yu Peng 1 , and Gao-Jun Teng 1
1
Jiangsu Key Laboratory of Molecular and
Functional Imaging, Department of Radiology, Zhongda
Hospita, Nanjing, Jiangsu, China
Type 2 diabetes mellitus (T2DM) has been shown to be
associated with an increased risk of dementia. However,
the etiology underlying is still largely unknown. The
default-mode network (DMN) is an important brain network
which supports several key functions. Dysfunction of DMN
has been suggested as an early marker of several
psychiatric disorders. This study aimed to investigate
the integrity of the DMN by using independent component
analysis (ICA) in T2DM patients and to correlate the DMN
functional connectivity (FC) changes with neurocognitive
performance and clinical variables. The disrupted DMN
could help imply the mechanism linking T2DM and
cognitive impairment.
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