Abstract #1912
Increased midbrain iron deposition in Parkinsons disease measured by quantitative susceptibility mapping
Guangwei Du 1 , Tian Liu 2 , Mechelle M. Lewis 1,3 , Jeffrey Vesek 4 , Lan Kong 5 , Martin Styner 6 , Qing X. Yang 4,7 , and Xuemei Huang 1,4
1
Department of Neurology, Penn State Hershey
Medical Center, Hershey, PA, United States,
2
MedImageMetric
LLC, New York, NY, United States,
3
Department
of Pharmacology, Penn State Hershey Medical Center,
Hershey, PA, United States,
4
Department
of Radiology, Penn State Hershey Medical Center,
Hershey, PA, United States,
5
Public Health
Sciences, Penn State Hershey Medical Center, Hershey,
PA, United States,
6
Department
of Computer Science, University of North Carolina,
Chapel Hill, NC, United States,
7
Department
of Neurosurgery, Penn State Hershey Medical Center,
Hershey, PA, United States
Parkinsons disease (PD) is the second most common
neurodegenerative disorder. Increased iron content in
the substantia nigra (SN) of PD patients has been
reported as a surrogate marker of PD. Quantitative
susceptibility mapping (QSM) has been proposed to
directly quantify iron content in human brain. In this
work, we examine the use of QSM as an in vivo marker(s)
of PD related pathology in nigrastriatal structures. Our
results showed increased susceptibility in the SN and
the RN in PD patients compared with controls. This study
supports the hypothesis that QSM can measure iron
accumulation associated with the PD-related pathological
process.
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