Abstract #1896
Quantitative cerebral water content changes after CSF removal in idiopathic normal pressure hydrocephalus: a preliminary analysis using MRI at 3 T
Zaheer Abbas 1 , Kathrin Reetz 1,2 , Ana Sofia Costa 2 , Vincent Gras 1 , Shahram Mirzazade 1,2 , Johannes Schiefer 2 , Georg Neuloh 3 , Jrg Bernhard Schulz 2,4 , and N Jon Shah 1,2
1
INM-4, Research Centre Jlich GmbH, Jlich,
Germany,
2
Department
of Neurology, RWTH Aachen University, Aachen, Germany,
3
Department
of Neurosurgery, RWTH Aachen University Hospital,
Aachen, Germany,
4
Translational
Brain Medicine, Jlich Aachen Research Alliance (JARA),
Jlich and Aachen, Germany
Proton density (PD) is tightly regulated in the human
brain. Quantitative measures of PD have provided new
insights into monitoring disease progression. MRI
protocols were set up to quantitatively assess PD in
idiopathic normal pressure hydrocephalus (iNPH)
patients, before and after cerebrospinal fluid (CSF)
removal by lumbar puncture. Data were co-registered to
the MNI brain template and PD mean values for total
white matter (WM), total grey matter (GM), frontal,
parietal, occipital and temporal WM and GM were
determined. Although, no changes in GM were found,
increased water content in WM (about 3%) in iNPH
decreased after lumbar puncture.
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